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Literature summary for 2.4.2.12 extracted from

  • Zhang, R.Y.; Qin, Y.; Lv, X.Q.; Wang, P.; Xu, T.Y.; Zhang, L.; Miao, C.Y.
    A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase (2011), Anal. Biochem., 412, 18-25.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
(4',5,7-trihydroxyflavone)-(3'->8)-(4',5,7-trihydroxyflavone)
-
Mus musculus
(4',7-dimethoxy-5-hydroxyflavone)-(3'->8)-(4',7-dimethoxy-5-hydroxyflavone)
-
Mus musculus
FK-866 i.e. (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-phenylprop-2-enamide Mus musculus
gallotanine i.e. (2R,3S,5R,6S)-tetrahydro-2H-pyran-2,3,4,5,6-pentaylpentakis(oxycarbonyl-5,6-dihydroxybenzene-3,1-diyl) pentakis(3,4,5-trihydroxybenzoate) Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
immobilized metal ion affinity chromatography Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + 5-phosphoribosyl 1-diphosphate
-
Mus musculus nicotinamide mononucleotide + diphosphate
-
?

Synonyms

Synonyms Comment Organism
nicotinamide phosphoribosyltransferase
-
Mus musculus
PBEF
-
Mus musculus
Visfatin
-
Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000009
-
i.e. (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-phenylprop-2-enamide, pH 7.5, 37°C Mus musculus FK-866
0.0013
-
i.e. (2R,3S,5R,6S)-tetrahydro-2H-pyran-2,3,4,5,6-pentaylpentakis(oxycarbonyl-5,6-dihydroxybenzene-3,1-diyl) pentakis(3,4,5-trihydroxybenzoate), pH 7.5, 37°C Mus musculus gallotanine
0.0066
-
pH 7.5, 37°C Mus musculus (4',5,7-trihydroxyflavone)-(3'->8)-(4',5,7-trihydroxyflavone)
0.0175
-
pH 7.5, 37°C Mus musculus (4',7-dimethoxy-5-hydroxyflavone)-(3'->8)-(4',7-dimethoxy-5-hydroxyflavone)