Literature summary for 2.4.2.12 extracted from

Mercader, J.; Granados, N.; Caimari, A.; Oliver, P.; Bonet, M.L.; Palou, A.
Retinol-binding protein 4 and nicotinamide phosphoribosyltransferase/visfatin in rat obesity models (2008), Horm. Metab. Res., 40, 467-472.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
nicotinamide + alpha-D-5-phosphoribosyl-1-diphosphate	Rattus norvegicus	-	nicotinamide mononucleotide + diphosphate	-	r

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q80Z29	male Wistar rats, six-months-old, develop diet-induced hyperphagia and obesity, male obese (fa/fa) Zucker rats, three-months-old, display genetic obesity due to deficit in leptin receptors, and male lean Zucker rats, three-month-old	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood serum	similar mRNA expression levels in (fa/fa) Zucker rats (obese) compared to lean Zucker rats (control) as well as in cafeteria diet-fed Wistar rats (diet-induced obesity) compared to standard chow diet-fed Wistar rats (control)	Rattus norvegicus	-
groin	inguinal white adipose tissue	Rattus norvegicus	-
visceral fat	similar mRNA expression levels in mesenteric, retroperitoneal and epididymal WAT depots of (fa/fa) Zucker rats (obese) compared to lean Zucker rats (control)	Rattus norvegicus	-
white adipose tissue	lean Wistar rats: mRNA expression levels are maximal in mesenteric WAT (2.01 +/-0.08) followed by inguinal (1.23 +/-0.15), epididymal (0.88 +/-0.13), and retroperitoneal (0.79 +/-0.07) WAT	Rattus norvegicus	-
white adipose tissue	lean Zucker rats: mRNA expression levels are similar in subcutaneous (inguinal, 1.18 +/-0.33) and visceral (mesenteric (0.99 +/-0.15), retroperitoneal (0.56 +/-0.10), epididymal (1.17 +/-0.14)) WAT	Rattus norvegicus	-
white adipose tissue	mesenteric, significantly decreased mRNA expression level in cafeteria diet-fed Wistar rats (diet-induced obesity) compared to standard chow diet-fed Wistar rats (control)	Rattus norvegicus	-
white adipose tissue	significantly reduced mRNA expression level in (fa/fa) Zucker rats (obese) compared to lean Zucker rats (control) and in cafeteria diet-fed Wistar rats (diet-induced obesity) compared to standard chow diet-fed Wistar rats (control)	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nicotinamide + alpha-D-5-phosphoribosyl-1-diphosphate	-	Rattus norvegicus	nicotinamide mononucleotide + diphosphate	-	r

Synonyms

Synonyms	Comment	Organism
Nampt	-	Rattus norvegicus
Nampt/visfatin	-	Rattus norvegicus
nicotinamide phosphoribosyltransferase	-	Rattus norvegicus
pre-B cell colony enhancing factor	-	Rattus norvegicus
Visfatin	-	Rattus norvegicus

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Release 2023.1 (January 2023)