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Literature summary for 2.4.2.10 extracted from
- Clinical role of orotate phosphoribosyl transferase and dihydropyrimidine dehydrogenase in colorectal cancer treated with postoperative fluoropyrimidine (2007), Surgery, 141, 346-353.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | OPRT expression is negatively associated with colorectal cancer progression | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | essential enzyme for activation of 5-fluorouracil and its derivatives | 5-fluorouridine 5'-phosphate + diphosphate | - |
? |  |
| additional information | Homo sapiens | relationship between OPRT, antagonizing dihydropyrimidine dehydrogenase, and clinicopathologic features in cancer and treatment with 5-fluorouracil, relation of patients survival and enzyme activities after surgery, detailed overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colonic cancer cell | colorectal cancer, 150 patients with cancer at different stages, stage-related enzyme expression level, overview | Homo sapiens | - |
| colorectal cancer cell | - |
Homo sapiens | - |
| lymph node cancer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | 5-fluorouridine 5'-phosphate + diphosphate | - |
? | |
| 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate | essential enzyme for activation of 5-fluorouracil and its derivatives | Homo sapiens | 5-fluorouridine 5'-phosphate + diphosphate | - |
? | |
| additional information | relationship between OPRT, antagonizing dihydropyrimidine dehydrogenase, and clinicopathologic features in cancer and treatment with 5-fluorouracil, relation of patients survival and enzyme activities after surgery, detailed overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| OPRT | - |
Homo sapiens |
| orotate phosphoribosyl transferase | - |
Homo sapiens |
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