Application | Comment | Organism |
---|---|---|
medicine | for inhibitor (S)-3-(guanin-9-yl)pyrrolidin-N-ylcarbonylphosphonic acid, Ki values widely vary from 16 to 100 nM for enzyme from cancer cell lines. For inhibitor (3S,4R)-4-(guanin-9-yl)-3-hydroxypyrrolidin-1-N-ylcarbonylphosphonic acid, Ki values are around 10 to 24 nM for enzyme from cancer cell lines | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3S,4R)-4-(guanin-9-yl)-3-hydroxypyrrolidin-1-N-ylcarbonylphosphonic acid | competitive. For enzyme from cancer cell lines, Ki values are around 10 to 24 nM | Homo sapiens | |
(S)-3-(guanin-9-yl)pyrrolidin-N-ylcarbonylphosphonic acid | competitive. For enzyme from cancer cell lines, Ki values widely vary from 16 to 100 nM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
7-N-methyl-6-thiopurine riboside | enzyme purified from mantle cell lymphoma, pH 7.5, temperature not specified in the publication | Homo sapiens | |
0.04 | - |
7-N-methyl-6-thiopurine riboside | enzyme purified from diffuse large B-cell lymphoma progressed from follicular lymphoma, pH 7.5, temperature not specified in the publication | Homo sapiens | |
0.05 | - |
phosphate | enzyme purified from peripheral blood mononuclear cell, pH 7.5, temperature not specified in the publication | Homo sapiens | |
0.06 | - |
7-N-methyl-6-thiopurine riboside | recombinant enzyme, pH 7.5, temperature not specified in the publication | Homo sapiens | |
0.08 | - |
7-N-methyl-6-thiopurine riboside | enzyme purified from peripheral blood mononuclear cell, pH 7.5, temperature not specified in the publication | Homo sapiens | |
0.1 | - |
phosphate | recombinant enzyme, pH 7.5, temperature not specified in the publication | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PBMC cell | peripheral blood mononuclear cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-N-methyl-6-thiopurine riboside + phosphate | - |
Homo sapiens | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
(3S,4R)-4-(guanin-9-yl)-3-hydroxypyrrolidin-1-N-ylcarbonylphosphonic acid | recombinant enzyme, pH 7.5, temperature not specified in the publication | Homo sapiens | |
0.02 | - |
(S)-3-(guanin-9-yl)pyrrolidin-N-ylcarbonylphosphonic acid | recombinant enzyme, pH 7.5, temperature not specified in the publication | Homo sapiens |