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Literature summary for 2.4.2.1 extracted from

  • Vande Voorde, J.; Quintiliani, M.; McGuigan, C.; Liekens, S.; Balzarini, J.
    Inhibition of pyrimidine and purine nucleoside phosphorylases by a 3,5-dichlorobenzoyl-substituted 2-deoxy-D-ribose-1-phosphate derivative (2012), Biochem. Pharmacol., 83, 1358-1363.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate
-
Homo sapiens
3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate competitive inhibition with regard to inosine Mycoplasma hyorhinis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.491
-
Inosine pH 7.6, 37°C Homo sapiens
1.796
-
Inosine pH 7.6, 37°C Mycoplasma hyorhinis

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mycoplasma hyorhinis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine + phosphate
-
Homo sapiens hypoxanthine + alpha-D-ribose 1-phosphate
-
?
inosine + phosphate
-
Mycoplasma hyorhinis hypoxanthine + alpha-D-ribose 1-phosphate
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.27
-
pH 7.6, 37°C Mycoplasma hyorhinis 3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate
0.372
-
pH 7.6, 37°C Homo sapiens 3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate