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Literature summary for 2.4.2.1 extracted from

  • Eustaquio, A.S.; McGlinchey, R.P.; Liu, Y.; Hazzard, C.; Beer, L.L.; Florova, G.; Alhamadsheh, M.M.; Lechner, A.; Kale, A.J.; Kobayashi, Y.; Reynolds, K.A.; Moore, B.S.
    Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine (2009), Proc. Natl. Acad. Sci. USA, 106, 12295-12300.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information generation of a salT-deficient mutant strain Salinispora tropica

Organism

Organism UniProt Comment Textmining
Salinispora tropica B0L7E7 gene salT
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-chloro-5'-deoxy-adenosine + phosphate
-
Salinispora tropica 5-chloro-5-deoxy-D-ribose 1-phosphate + adenine
-
?

Synonyms

Synonyms Comment Organism
purine nucleoside phosphorylase
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Salinispora tropica
SalT
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Salinispora tropica

General Information

General Information Comment Organism
malfunction the salT-deficient mutant strain shows reduced salinosporamide A and salinosporamide B synthesis Salinispora tropica
metabolism the enzyme is involved in the chloroethylmalonyl-CoA biosynthetic pathway, overview Salinispora tropica