Literature summary for 2.4.2.1 extracted from

Cai, X.; Zhou, J.; Chang, Y.; Sun, X.; Li, P.; Lin, J.
Targeting gene therapy for hepatocarcinoma cells with the E. coli purine nucleoside phosphorylase suicide gene system directed by a chimeric alpha-fetoprotein promoter (2008), Cancer Lett., 264, 71-82.

Search for more literature for 2.4.2.1

Application

Application	Comment	Organism
medicine	expression of the Escherichia coli purine nucleoside phosphorylase/9-(2-deoxy-beta-dribofuranosyl)-6-methylpurine suicide gene system in human hepatocarcinoma cells together with a chimeric human alpha-fetoprotein promoter. In the presence of hypoxia, the Escherichia coli purine nucleoside phosphorylase gene directed by the human promoter is specifically expressed in two human hepatocarcinoma cell lines and, the therapy yields significant and selective cytotoxicity in both alpha-fetoprotein-positive and low-alpha-fetoprotein-generating hepatocarcinoma cells	Escherichia coli

Cloned(Commentary)

Cloned (Comment)	Organism
expression of the Escherichia coli purine nucleoside phosphorylase/9-(2-deoxy-beta-dribofuranosyl)-6-methylpurine suicide gene system in human hepatocarcinoma cells	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)