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Literature summary for 2.4.2.1 extracted from

  • Furman, R.R.; Hoelzer, D.
    Purine nucleoside phosphorylase inhibition as a novel therapeutic approach for B-cell lymphoid malignancies (2007), Semin. Oncol., 34, S29-S34.
    View publication on PubMed
Search for more literature for 2.4.2.1

Application

Application Comment Organism
medicine endogenous PNP deficiency leads to specific T-cell immunodeficiency, a genetic disease. PNP inhibition leads to the elevation of 2'-deoxyguanosine levels and accumulation of intracellular deoxyguanosine 5'-triphosphate, inducing cellular apoptosis. Forodesine is a highly potent, orally active, rationally designed PNP inhibitor that is active in preclinical studies with malignant cells and clinical utility against T-cell acute lymphoblastic leukemia and cutaneous T-cell lymphoma Homo sapiens
medicine purine nucleoside phosphorylase inhibition is a novel therapeutic approach for B-cell lymphoid malignancies Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
forodesine a highly potent, orally active, rationally designed PNP inhibitor, that is active in preclinical studies with malignant cells and clinical utility against T-cell acute lymphoblastic leukemia and cutaneous T-cell lymphoma; a highly potent, orally active, rationally designed PNP inhibitor, use for the management of some B-cell malignancies Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2'-deoxyguanosine + phosphate Homo sapiens
-
 guanine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxyguanosine + phosphate
-
 Homo sapiens guanine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PNP
-
 Homo sapiens