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Literature summary for 2.4.2.1 extracted from

  • Mason, J.M.; Murkin, A.S.; Li, L.; Schramm, V.L.; Gainsford, G.J.; Skelton, B.W.
    A beta-fluoroamine inhibitor of purine nucleoside phosphorylase (2008), J. Med. Chem., 51, 5880-5884.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
(3R,4R)-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol
-
 Homo sapiens
(3S,4S)-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol
-
 Homo sapiens
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
-
 Homo sapiens
cis-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethylpyrrolidin-3-ol
-
 Homo sapiens
L-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000000011
-
 4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H overall dissociation constant Homo sapiens
0.000000032
-
 (3S,4S)-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol overall dissociation constant Homo sapiens
0.000000066
-
 cis-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethylpyrrolidin-3-ol overall dissociation constant Homo sapiens
0.00000038
-
 L-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-H slow-onset binding constant Homo sapiens
0.00000182
-
 (3R,4R)-1-((9-deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol overall dissociation constant Homo sapiens