Literature summary for 2.4.2.1 extracted from

Wierzchowski, J.; Stepniak, K.; Bzowska, A.; Shugar, D.
Spectroscopic and kinetic studies of interactions of calf spleen purine nucleoside phosphorylase with 8-azaguanine, and its 9-(2-phosphonylmethoxyethyl) derivative (2005), Nucleosides Nucleotides Nucleic Acids, 24, 459-464.

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Inhibitors

Inhibitors	Comment	Organism	Structure
9-(2-phosphonylmethoxyethyl)-8-azaguanine	competitive versus 8-azaguanine and alpha-D-ribose 1-phosphate	Bos taurus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.09	-	8-Azaguanine	pH 5.9	Bos taurus
0.7	-	8-Azaguanine	pH 8	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spleen	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7-methyladenosine + phosphate	-	Bos taurus	7-methyladenine + alpha-D-ribose 1-phosphate	-	?
8-azaguanine + alpha-D-ribose 1-phosphate	-	Bos taurus	8-azaguanosine + phosphate	-	?

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Release 2023.1 (January 2023)