Literature summary for 2.4.2.1 extracted from

Iwanow, M.; Magnowska, L.; Yokomatsu, T.; Shibuya, S.; Bzowska, A.
Interactions of potent multisubstrate analogue inhibitors with purine nucleoside phosphorylase from calf spleen--kinetic and spectrofluorimetric studies (2003), Nucleosides Nucleotides Nucleic Acids, 22, 1567-1570.

Search for more literature for 2.4.2.1

Inhibitors

Inhibitors	Comment	Organism	Structure
(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranozyl)ethylphosphonic acid	with (hypoxanthine-9-yl)methyl aglycone, i.e. Yokomatsu compound	Bos taurus
9-(5,5-difluoro-5-phosphonopentyl)guanine	i.e. Danzin compound	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spleen	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7-methylguanosine + phosphate	-	Bos taurus	7-methylguanine + alpha-D-ribose 1-phosphate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000001	-	(+/-)-cis-1,1-difluoro-2-(tetrahydro-3-piranozyl)ethylphosphonic acid	approximate value, with (hypoxanthine-9-yl)methyl aglycone, i.e. Yokomatsu compound	Bos taurus
0.000002	-	9-(5,5-difluoro-5-phosphonopentyl)guanine	approximate value	Bos taurus

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Release 2023.1 (January 2023)