Crystallization (Comment) | Organism |
---|---|
structures of the enzyme complexed with 2-fluoro-2'-deoxyadenosine, formycin A, adenosine, inosine or 2'-deoxyinosine determined at resolutions ranging from 2.4 to 2.9 A | Trichomonas vaginalis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-fluoro-2'-deoxyadenosine | the substrate releases highly cytotoxic 2-fluoroadenine. 2-Fluoro-2'-deoxyadenosine and 2-fluoroadenine exert strong inhibition of Trichomonas vaginalis growth with estimated IC50 values of 106 nM and 84 nM. 2-Fluoro-2'-deoxyadenosine might be useful as a potential chemotherapeutic agent against Trichomonas vaginalis | Trichomonas vaginalis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trichomonas vaginalis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-fluoro-2-deoxyadenosine + phosphate | - |
Trichomonas vaginalis | adenine + 2-fluoro-2-deoxy-alpha-D-ribose 1-phosphate | the product 2-fluoroadenine is highly cytotoxic for Trichomonas vaginalis | ? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000106 | 0.000084 | the substrate releases highly cytotoxic 2-fluoroadenine. 2-Fluoro-2'-deoxyadenosine and 2-fluoroadenine exert strong inhibition of Trichomonas vaginalis growth with estimated IC50 values of 106 nM and 84 nM. 2-Fluoro-2'-deoxyadenosine might be useful as a | Trichomonas vaginalis | 2-fluoro-2'-deoxyadenosine |