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Literature summary for 2.4.2.1 extracted from

  • Koellner, G.; Bzowska, A.; Wielgus-Kutrowska, B.; Luic, M.; Steiner, T.; Saenger, W.; Stepinski, J.
    Open and closed conformation of the E. coli purine nucleoside phosphorylase active center and implications for the catalytic mechanism (2002), J. Mol. Biol., 315, 351-371.
    View publication on PubMed
Search for more literature for 2.4.2.1

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop method, crystal structure of the ternary complex of the hexameric enzyme with formycin A derivatives and phosphate or sulfate ions is determined at 2.0 A resolution Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
6-methylformycin
-
 Escherichia coli
Formycin A
-
 Escherichia coli
formycin B
-
 Escherichia coli
N(6)-Methylformycin A
-
 Escherichia coli
N(7)-methylformycin A
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P0ABP8
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00027
-
 N(6)-methyl-formycin A pH 8.0 Escherichia coli
0.0003
-
 N(6)-methyl-formycin A pH 7 Escherichia coli
0.0022
-
 N(7)-methylformycin A pH 5.5 Escherichia coli
0.0046
-
 formycin B pH 7 Escherichia coli
0.005
-
 6-methylformycin A pH 6.0 Escherichia coli
0.0053
-
 Formycin A pH 7.0 Escherichia coli
0.0138
-
 Formycin A pH 5.5 Escherichia coli
0.0252
-
 6-methylformycin A pH 5.5 Escherichia coli