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Literature summary for 2.4.1.B7 extracted from

  • Mackenzie, P.I.; Rogers, A.; Treloar, J.; Jorgensen, B.R.; Miners, J.O.; Meech, R.
    Identification of UDP glycosyltransferase 3A1 as a UDP N-Acetylglucosaminyltransferase (2008), J. Biol. Chem., 283, 36205-36210.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.B7

Application

Application Comment Organism
medicine important role in therapies for ameliorating the symptoms of cholestasis or for dissolving gallstones Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK293T cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C121G a polymorphic UGT3A1 variant containing a C121G substitution is catalytically inactive Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.049
-
 ursodeoxycholate pH 7.5, 37°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
 x * 53000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + ursodeoxycholate Homo sapiens i.e. 3',7'-dihydroxy-5'-cholanoic acid. Important role in the metabolism and elimination of ursodeoxycholic acid UDP + 7beta-(N-acetyl-D-glucosaminyl)-ursodeoxycholate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastrointestinal tract poor activity Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information also transfers N-acetyl-D-glucosamine to 17alpha-estradiol, 17beta-estradiol, 4-nitrophenol and 1-naphthol Homo sapiens ?
-
 ?
UDP-N-acetyl-D-glucosamine + ursodeoxycholate i.e. 3',7'-dihydroxy-5'-cholanoic acid. Important role in the metabolism and elimination of ursodeoxycholic acid Homo sapiens UDP + 7beta-(N-acetyl-D-glucosaminyl)-ursodeoxycholate
-
 ?
UDP-N-acetyl-D-glucosamine + ursodeoxycholate i.e. 3',7'-dihydroxy-5'-cholanoic acid. The enzyme uses ursodeoxycholic acid and UDP N-acetylglucosamine in preference to other primary and secondary bile acids, and other UDP sugars such as UDP glucose, UDP glucuronic acid, UDP galactose, and UDP xylose Homo sapiens UDP + 7beta-(N-acetyl-D-glucosaminyl)-ursodeoxycholate
-
 ?

Subunits

Subunits Comment Organism
? x * 53000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
UDP glycosyltransferase 3A1
-
 Homo sapiens
UGT3A1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens