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Literature summary for 2.4.1.B62 extracted from

  • Just, I.; Selzer, J.; Hofmann, F.; Green, G. A.; Aktories, K.
    Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation (1996), J. Biol. Chem., 271, 10149-10153.
    View publication on PubMed
Search for more literature for 2.4.1.B62

Inhibitors

Inhibitors Comment Organism Structure
EDTA 2 mM, complete inhibition Paeniclostridium sordellii

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ stimulation, maximum activity at 1 mM Paeniclostridium sordellii

Organism

Organism UniProt Comment Textmining
Paeniclostridium sordellii Q46342 cytotoxin L
-
Paeniclostridium sordellii 6018 Q46342 cytotoxin L
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information lethal toxin from Clostridium sordellii is a glucosyltransferase, which uses UDP-glucose as cosubstrate to modify low molecular mass GTPases. Lethal toxin selectively modifies Rac and Ras. In Rac, acceptor amino acid is residue threonine 35. No substrates: Rho, Cdc42, Rab, Arf Paeniclostridium sordellii ?
-
 ?
additional information lethal toxin from Clostridium sordellii is a glucosyltransferase, which uses UDP-glucose as cosubstrate to modify low molecular mass GTPases. Lethal toxin selectively modifies Rac and Ras. In Rac, acceptor amino acid is residue threonine 35. No substrates: Rho, Cdc42, Rab, Arf Paeniclostridium sordellii 6018 ?
-
 ?
UDP-alpha-D-glucose + H-Ras Ras is the exclusive substrate of the Ras subfamily of GTPases. Ras is a better substrate in the GTDP-bound form than in the GTP-bound form Paeniclostridium sordellii UDP + D-glucosyl-H-Ras
-
 ?
UDP-alpha-D-glucose + H-Ras Ras is the exclusive substrate of the Ras subfamily of GTPases. Ras is a better substrate in the GTDP-bound form than in the GTP-bound form Paeniclostridium sordellii 6018 UDP + D-glucosyl-H-Ras
-
 ?
UDP-alpha-D-glucose + Rac1 Rac is the exclusive substrate of the Rho subfamily of GTPases. Rac is a better substrate in the GTDP-bound form than in the GTP-bound form Paeniclostridium sordellii UDP + D-glucosyl-Rac1
-
 ?
UDP-alpha-D-glucose + Rac1 Rac is the exclusive substrate of the Rho subfamily of GTPases. Rac is a better substrate in the GTDP-bound form than in the GTP-bound form Paeniclostridium sordellii 6018 UDP + D-glucosyl-Rac1
-
 ?

Synonyms

Synonyms Comment Organism
lethal toxin
-
 Paeniclostridium sordellii

General Information

General Information Comment Organism
physiological function glucosylation of Ras by lethal toxin results in inhibition of the epidermal growth factor-stimulated p42/p44 MAP-kinase signal pathway Paeniclostridium sordellii