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Literature summary for 2.4.1.92 extracted from

  • Senn, H.J.; Cooper, C.; Warnke, P.C.; Wagner, M.; Decker, K.
    Ganglioside biosynthesis in rat liver. Characterization of UDP-N-acetylgalactosamine - GM3 acetylgalactosaminyltransferase (1981), Eur. J. Biochem., 120, 59-67.
    View publication on PubMed
Search for more literature for 2.4.1.92

Activating Compound

Activating Compound Comment Organism Structure
cardiolipin
-
 Rattus norvegicus
Detergents requirement, solubilized enzyme, e.g. Triton X-100 Rattus norvegicus
octylglucoside activation Rattus norvegicus
octylglucoside optimal: 0.8% Rattus norvegicus
Triton X-100
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
adenosine-5'-[alpha,beta-methylene]triphosphate
-
 Rattus norvegicus
CMP
-
 Rattus norvegicus
IMP
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.035
-
 UDP-N-acetyl-D-galactosamine
-
 Rattus norvegicus
0.1
-
 GM3
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Rattus norvegicus 5794
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ not Rattus norvegicus
Cd2+ activation, can replace Mn2+ to some extent Rattus norvegicus
Co2+ activation, can replace Mn2+ to some extent Rattus norvegicus
Fe2+ activation, can replace Mn2+ Rattus norvegicus
Mg2+ not Rattus norvegicus
Mn2+
-
 Rattus norvegicus
additional information no activation by Ba2+ Rattus norvegicus
Ni2+ can replace Mn2+ to some extent Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0004 0.0005
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide from human spleen or rat liver Homo sapiens UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
-
 ?
UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide from human spleen or rat liver Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide i.e. GM2(N-acetylneuraminic acid)-ganglioside ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
 Rattus norvegicus