Protein Variants | Comment | Organism |
---|---|---|
I285Y | site-directed mutagenesis, the mutation converts the betaGALNAcT1 enzyme into an efficient beta4Gal-T1, the N-acetylgalactosaminyltransferase activity is reduced by nearly 1000fold, while the galactosyltransferase activity is enhanced by 80fold | Drosophila melanogaster |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-lactalbumin | inhibits the GalNAc transferase activity of the enzyme | Drosophila melanogaster |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | required | Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Drosophila melanogaster | the preexisting alpha-lactalbumin-binding site iss utilized during mammalian evolution to synthesize lactose in the mammary gland during lactation | ? | - |
? | |
UDP-galactose + N-acetylglucosamine | Drosophila melanogaster | - |
UDP + N-acetyllactosamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the preexisting alpha-lactalbumin-binding site iss utilized during mammalian evolution to synthesize lactose in the mammary gland during lactation | Drosophila melanogaster | ? | - |
? | |
UDP-galactose + N-acetylglucosamine | - |
Drosophila melanogaster | UDP + N-acetyllactosamine | - |
? | |
UDP-galactose + N-acetylglucosamine | wild-type enzyme, residue I285 alone is responsible for determination of enzyme substrate specificity, overview, active site structure, overview | Drosophila melanogaster | UDP + N-acetyllactosamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta1,4-galactosyltransferase-1 | - |
Drosophila melanogaster |
betaGALT1 | - |
Drosophila melanogaster |
GalT1 | - |
Drosophila melanogaster |
More | cf. EC 2.4.1.38 | Drosophila melanogaster |