Literature summary for 2.4.1.87 extracted from

Park, H.; Kim, Y.; Kim, K.; Kim, Y.; Yang, Y.; Jin, J.; Kim, Y.; Kim, B.; Shim, H.; Kim, Y.
Comparative n-linked glycan analysis of wild-type and alpha1,3-galactosyltransferase gene knock-out pig fibroblasts using mass spectrometry approaches (2015), Mol. Cells, 38, 65-74.

Search for more literature for 2.4.1.87

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of enzyme knockout mutant animals	Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R	Sus scrofa	-	UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R	-	?

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	cultured from ear skin biopsies	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R	-	Sus scrofa	UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R	-	?

Synonyms

Synonyms	Comment	Organism
alpha1,3-galactosyltransferase	-	Sus scrofa
GALT	-	Sus scrofa

General Information

General Information	Comment	Organism
malfunction	absence of galactose-alpha-1,3-galactose residue in the GalT-KO pig cells results in a higher level of overall fucosylated N-glycans in GalT-KO pig fibroblasts compared to wild-type pig fibroblasts, the relative quantity of the N-glycolylneuraminic acid antigen is also slightly higher in the GalT-KO pigs, mutant phenotype, overview	Sus scrofa
additional information	identification and quantification of 47 N-glycans from wild-type and enzyme kockout pig fibroblasts using MALDI-TOF mass spectrometry, overview	Sus scrofa

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Release 2023.1 (January 2023)