Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.86 extracted from

  • Chou, D.K.; Jungalwala, F.B.
    Characterization and developmental expression of lactotriosylceramide:galactosyltransferase for the synthesis of neolactotetraosylceramide in the nervous system (1994), J. Neurochem., 62, 307-314.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
deoxycholate required, most effective detergent Rattus norvegicus
detergent required for in vitro activity, deoxycholate is most effective Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.034
-
N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 4% of the activity with Mn2+ Rattus norvegicus
Mn2+ required Rattus norvegicus
Mn2+ optimal concentration is 10-15 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDPgalactose + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide Rattus norvegicus the enzyme catalyzes the terminal step in the synthesis of neolactotetraosylceramide UDP + 1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain adult cortex, activity is enriched 5fold higher in the white matter than in the gray matter of the young adult brain Rattus norvegicus
-
cerebellum specific activity is reduced by 50% soon after birth and then remains practically the same with development Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDPgalactose + GalNAcbeta1-4Galbeta1-4Glcbeta1-1ceramide 45% of the activity with N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide Rattus norvegicus UDP + Galbeta1,4-GalNAcbeta1-4Galbeta1-4Glcbeta1-1ceramide
-
?
UDPgalactose + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide
-
Rattus norvegicus UDP + 1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide
-
?
UDPgalactose + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide the enzyme catalyzes the terminal step in the synthesis of neolactotetraosylceramide Rattus norvegicus UDP + 1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
Rattus norvegicus