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Literature summary for 2.4.1.83 extracted from

  • Yamamoto, A.; Nakatsu, S.; Kondo, A.; Asato, T.; Okabe, M.; Fukuzawa, M.; Miyagawa, S.
    A newly cloned pig dolichyl-phosphate mannosyl-transferase for preventing the transmission of porcine endogenous retrovirus to human cells (2010), Transpl. Int., 23, 424-431.
    View publication on PubMed

Application

Application Comment Organism
medicine D-P-M enzyme activity represents a potentially useful approach to address the problem of porcine endogenous retrovirus infections in clinical xenotransplantations Sus scrofa

Cloned(Commentary)

Cloned (Comment) Organism
cDNA fragments containing the start and stop codons amplified and subcloned into the EcoRV site of the pBluescript II SK(-) cloning vector Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Synonyms

Synonyms Comment Organism
D-P-M
-
Sus scrofa
dolichyl-phosphate mannosyltransferase
-
Sus scrofa

Expression

Organism Comment Expression
Sus scrofa compared with the mock line, the temporary PEC(Z)/PB lines show a decreased mRNA expression for D-P-M and a clear destruction of porcine endogenous retrovirus infectivity to human cells in the Lac Z pseudotype assay. Compared with parental and mock cells, all PEC(Z)/PB cells transfected with siRNA show a decreased mRNA expression for the D-P-M by one-fifth down