Literature summary for 2.4.1.80 extracted from

Nomura, K.H.; Murata, D.; Hayashi, Y.; Dejima, K.; Mizuguchi, S.; Kage-Nakadai, E.; Gengyo-Ando, K.; Mitani, S.; Hirabayashi, Y.; Ito, M.; Nomura, K.
Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division (2011), Glycobiology, 21, 834-848.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in GM95 cells deficient in glycosphingolipids	Caenorhabditis elegans

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-glucose + ceramide	-	Caenorhabditis elegans	UDP + glucosylceramide	-	?
UDP-glucose + N-(epsilon-7-nitrobenz-2-oxa-1,3-diazol-4-yl-aminocaproyl)-D-erythro-sphingosine	-	Caenorhabditis elegans	?	-	?

Synonyms

Synonyms	Comment	Organism
ceramide glucosyltransferase	-	Caenorhabditis elegans
cgt-1	-	Caenorhabditis elegans
cgt-2	-	Caenorhabditis elegans
cgt-3	-	Caenorhabditis elegans
cgt-3	isoforms with highest activity	Caenorhabditis elegans
GlcT	-	Caenorhabditis elegans
UDP-glucose ceramide glucosyltransferase	-	Caenorhabditis elegans
Ugcg	-	Caenorhabditis elegans
uridine diphosphate (UDP)-glucose:N-acylsphingosine D-glucosyltransferase	-	Caenorhabditis elegans

General Information

General Information	Comment	Organism
malfunction	when each gene function is disrupted, the brood size of the animal markedly decreases and abnormal oocytes and multinucleated embryos are formed. Knockdown of the germline expression of gene cgt-3 results in abnormal oocyte formation and abnormal embryonic cell division	Caenorhabditis elegans
physiological function	the Ugcg gene is indispensable in the gremlin in oocyte formation and early embryonic division	Caenorhabditis elegans

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Release 2023.1 (January 2023)