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Literature summary for 2.4.1.80 extracted from

  • Gupta, V.; Patwardhan, G.A.; Zhang, Q.J.; Cabot, M.C.; Jazwinski, S.M.; Liu, Y.Y.
    Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase (GlcT-1) (2010), J. Lipid Res., 51, 866-874.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.80

Cloned(Commentary)

Cloned (Comment) Organism
expressed in different drug-resistant human cancer cell lines Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03877
-
 NBD C6-ceramide substrate is fluorescent Homo sapiens
0.04055
-
 C6-ceramide in tumor of NCI/ADR-RES Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + C6-ceramide with fluorescent NBD C6-ceramide resulting in NBD C6-glucosylceramide direct quantification of ceramide glycosylation catalyzed by GCS in cells and in tissues are possible Homo sapiens UDP + C6-glucosylceramide
-
 ?

Synonyms

Synonyms Comment Organism
GCS
-
 Homo sapiens
GlcT-1
-
 Homo sapiens
glucosylceramide synthase
-
 Homo sapiens
UDP-glucose ceramide glucosyltransferase
-
 Homo sapiens
Ugcg
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism key enzyme for the synthesis of glycosphingolipids which plays a role in physiology and diseases for instance in drug-resistant cancers Homo sapiens