Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | Fut8 partially localizes to the cell surface in an SH3-dependent manner | Homo sapiens | 9986 | - |
Golgi apparatus | Fut8 has an Src homology 3 (SH3) domain at the luminal side of the Golgi apparatus | Homo sapiens | 5794 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BYC5 | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | the SH3 domain of Fut8, located at the luminal side of the Golgi apparatus, is essential for FUT8 activity both in cells and in vitro. Residue His535 in the SH3 domain is the critical residue for enzymatic activity of FUT8. Ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, is an SH3-dependent binding protein of FUT8. RPN1 knockdown decreases both FUT8 activity and core fucose levels | Homo sapiens |