Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.68 extracted from

  • Tomida, S.; Takata, M.; Hirata, T.; Nagae, M.; Nakano, M.; Kizuka, Y.
    The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation (2020), J. Biol. Chem., 295, 7992-8004 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface Fut8 partially localizes to the cell surface in an SH3-dependent manner Homo sapiens 9986
-
Golgi apparatus Fut8 has an Src homology 3 (SH3) domain at the luminal side of the Golgi apparatus Homo sapiens 5794
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYC5
-
-

General Information

General Information Comment Organism
physiological function the SH3 domain of Fut8, located at the luminal side of the Golgi apparatus, is essential for FUT8 activity both in cells and in vitro. Residue His535 in the SH3 domain is the critical residue for enzymatic activity of FUT8. Ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, is an SH3-dependent binding protein of FUT8. RPN1 knockdown decreases both FUT8 activity and core fucose levels Homo sapiens