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Literature summary for 2.4.1.68 extracted from

  • Sasaki, H.; Toda, T.; Furukawa, T.; Mawatari, Y.; Takaesu, R.; Shimizu, M.; Wada, R.; Kato, D.; Utsugi, T.; Ohtsu, M.; Murakami, Y.
    alpha-1,6-Fucosyltransferase (FUT8) inhibits hemoglobin production during differentiation of murine and K562 human erythroleukemia cells (2013), J. Biol. Chem., 288, 16839-16847.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.68

Protein Variants

Protein Variants Comment Organism
D368A/K369A/V370A/G371A/T372A inactive mutant of the flexible loop Homo sapiens
D368A/K369A/V370A/G371A/T372A inactive mutant of the flexible loop Mus musculus
R365A/R366A inactive mutant of the donor substrate-binding domain Homo sapiens
R365A/R366A inactive mutant of the donor substrate-binding domain Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP-beta-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine Homo sapiens
-
 GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-beta-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine Mus musculus
-
 GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYC5
-
-
Mus musculus Q9WTS2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythroleukemia cell
-
 Homo sapiens
-
erythroleukemia cell
-
 Mus musculus
-
K-562 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-beta-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
 Homo sapiens GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-beta-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
 Mus musculus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?

Synonyms

Synonyms Comment Organism
alpha1,6-fucosyltransferase
-
 Homo sapiens
alpha1,6-fucosyltransferase
-
 Mus musculus
FUT8
-
 Homo sapiens
FUT8
-
 Mus musculus

Expression

Organism Comment Expression
Homo sapiens enzyme expression is positively regulated by c-Myc and c-Myb up
Mus musculus enzyme expression is positively regulated by c-Myc and c-Myb up

General Information

General Information Comment Organism
malfunction enzyme down-regulation promotes hemoglobin production and erythroid differentiation Homo sapiens
physiological function enzyme overexpression inhibits hemoglobin production in erythroleukemia cells Homo sapiens
physiological function enzyme overexpression inhibits hemoglobin production in erythroleukemia cells Mus musculus