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Literature summary for 2.4.1.68 extracted from

  • Ihara, H.; Ikeda, Y.; Toma, S.; Wang, X.; Suzuki, T.; Gu, J.; Miyoshi, E.; Tsukihara, T.; Honke, K.; Matsumoto, A.; Nakagawa, A.; Taniguchi, N.
    Crystal structure of mammalian {alpha}1,6-fucosyltransferase, FUT8 (2007), Glycobiology, 17, 455-466.
    View publication on PubMed
Search for more literature for 2.4.1.68

Cloned(Commentary)

Cloned (Comment) Organism
mutant enzymes expressed in COS-1 cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, crystal structure at 2.6 A resolution Homo sapiens

Protein Variants

Protein Variants Comment Organism
D368A inactive mutant enzyme Homo sapiens
D409A inactive mutant enzyme Homo sapiens
D410A mutant enzyme is fully active, similar to the wild-type enzyme Homo sapiens
D453A inactive mutant enzyme Homo sapiens
E373A inactive mutant enzyme Homo sapiens
K369A inactive mutant enzyme Homo sapiens
S469A inactive mutant enzyme Homo sapiens
Y382A inactive mutant enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine Homo sapiens alpha1,6-fucosylation, also referred to as core fucosylation, plays an essential role in various pathophysiological events. FUT8 null mice shows severe growth retardation and emphysema-like lung-destruction as a result of the dysfunction of epidermal growth factor and transforming growth factor-beta receptors GDP + N4-(N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl)asparagine
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYC5
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine alpha1,6-fucosylation, also referred to as core fucosylation, plays an essential role in various pathophysiological events. FUT8 null mice shows severe growth retardation and emphysema-like lung-destruction as a result of the dysfunction of epidermal growth factor and transforming growth factor-beta receptors Homo sapiens GDP + N4-(N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl)asparagine
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 ?

Synonyms

Synonyms Comment Organism
FUT8
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 Homo sapiens