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Literature summary for 2.4.1.65 extracted from

  • Fagerberg, D.; Angstroem, J.; Halim, A.; Hultberg, A.; Rakhimova, L.; Hammarstroem, L.; Boren, T.; Teneberg, S.
    Novel Leb-like Helicobacter pylori-binding glycosphingolipid created by the expression of human alpha-1,3/4-fucosyltransferase in FVB/N mouse stomach (2009), Glycobiology, 19, 182-191.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of alpha-1,3/4-fucosyltransferase in the gastric pit cell lineage of FVB/N transgenic mice Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
alpha-1,3/4-fucosyltransferase
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Homo sapiens

General Information

General Information Comment Organism
physiological function Helicobacter pylori-binding glycosphingolipid isolated from stomach of transgenic alpha-1,3/4-fucosyltransferase-expressing mice as a Fucalpha2Galbeta3 (Fucalpha4)GalNAcbeta4Galbeta4Glcbeta1Cer, i.e. a Leb-like glycosphingolipid on a ganglio core structure. Two other glycosphingolipids are isolated from the mouse stomach epithelium that are found to be nonbinding with regard to Helicobacter pylori, which is a pentaglycosylceramide, GalNAcbeta3Galalpha3(Fucalpha2)Galbeta4Glcbeta1Cer, in which the isoglobo tetrasaccharide is combined with Fucalpha2 to yield an isoglobotetraosylceramide with an internal blood group B determinant. The second one is an elongated fucosyl-gangliotetraosylceramide, GalNAcbeta3(Fucalpha2)Galbeta3GalNAcbeta4Galbeta4Glcbeta1Cer Homo sapiens