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Literature summary for 2.4.1.65 extracted from

  • Khaled, A.; Piotrowska, O.; Dominiak, K.; Auge, C.
    Exploring specificity of glycosyltransferases: synthesis of new sugar nucleotide related molecules as putative donor substrates (2008), Carbohydr. Res., 343, 167-178.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
9-(5'-O-[(alpha,beta-L-fucopyranosyl)oxycarbonylaminosulfonyl]-beta-D-ribofuranosyl)-guanine poor competitive inhibition Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ absolutely required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-beta-L-fucose + beta-D-Galp-(1,3)-beta-D-GlcNAcp-O-(CH2)6-NH-dansyl
-
Homo sapiens GDP + beta-D-Galp-(1,3)[alpha-L-Fuc-(1,4)]-beta-D-GlcNAcp-O-(CH2)6-NH-dansyl
-
?
additional information FucT-III catalyzes the transfer of fucose onto position-4 or position-3 of the N-acetylglucosamine unit of disaccharides beta-D-Galp-(1,3)-beta-D-GlcpNAc or beta-D-Galp-(1,4)-beta-D-GlcpNAc, respectively. FucT-III is an inverting enzyme Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
alpha-(1-3/4)-fucosyltransferase
-
Homo sapiens
FucT-III
-
Homo sapiens
GDP-Fuc: beta-D-Galp-(1-3/4)-beta-D-GlcpNAc-(1-4'/3')-alpha-fucosyltransferase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
20
-
-
Homo sapiens 9-(5'-O-[(alpha,beta-L-fucopyranosyl)oxycarbonylaminosulfonyl]-beta-D-ribofuranosyl)-guanine