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Literature summary for 2.4.1.62 extracted from

  • Franken, S.; Wittke, D.; Mansson, J.E.; DHooge, R.; De Deyn, P.P.; Luellmann-Rauch, R.; Matzner, U.; Gieselmann, V.
    Modest phenotypic improvements in ASA-deficient mice with only one UDP-galactose:ceramide-galactosyltransferase gene (2006), Lipids Health Dis., 5, 21.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus mice heterozygous for a non-functional allele of UDPgalactose:ceramide-galactosyltransferase show decreased synthesis of galactosylceramide and sulfatide, which should reduce sulfatide storage and improve pathology in arylsulfatase A-deficient mice. The phenotypic and pathologic improvements in ASA-/- CGT+/- mice are significant but overall minor ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information mice heterozygous for a non-functional allele of UDPgalactose:ceramide-galactosyltransferase show decreased synthesis of galactosylceramide and sulfatide, which should reduce sulfatide storage and improve pathology in arylsulfatase A-deficient mice. The phenotypic and pathologic improvements in ASA-/- CGT+/- mice are significant but overall minor Mus musculus ?
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