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Literature summary for 2.4.1.62 extracted from

  • Bellman Yip, G.; Dain, J.A.
    The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide galactosyltransferase in rat brain (1970), Biochim. Biophys. Acta, 206, 252-260.
    View publication on PubMed
Search for more literature for 2.4.1.62

Activating Compound

Activating Compound Comment Organism Structure
Detergents required Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
 Rattus norvegicus
GM2 0.35 mM and above Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
 UDP-galactose
-
 Rattus norvegicus
0.094
-
 N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome in fetal brain Rattus norvegicus
-
-
mitochondrion in fetal and adult brain Rattus norvegicus 5739
-
additional information subcellular distribution is dependent on the developmental stage Rattus norvegicus
-
-
nucleus in adult brain Rattus norvegicus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Rattus norvegicus
additional information no activation by Mg2+ Rattus norvegicus
additional information no activation by K+, Al3+ Rattus norvegicus
additional information no activation Ni2+, Cu2+ Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley
-
Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no substrates are GM3, GM1, GD1a and GT1 gangliosides, glucocerebroside, lactosylceramide, trihexosylceramide Rattus norvegicus ?
-
 ?
additional information no substrates are GM3, GM1, GD1a and GT1 gangliosides, glucocerebroside, lactosylceramide, trihexosylceramide Rattus norvegicus Sprague-Dawley ?
-
 ?
UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine donor and acceptor specificity, overview Rattus norvegicus UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine i.e. GM1 ganglioside or monosialoganglioside ?
UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine donor and acceptor specificity, overview Rattus norvegicus Sprague-Dawley UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine i.e. GM1 ganglioside or monosialoganglioside ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7.2 broad Rattus norvegicus