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Literature summary for 2.4.1.54 extracted from
- Studies on the biosynthesis of mannan in Micrococcus lysodeikticus. II. The enzymatic synthesis of mannosyl-l-phosphoryl-undecaprenol (1969), J. Biol. Chem., 244, 5890-5898.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Cutscum | activates | Micrococcus luteus | |
| Detergents | activate | Micrococcus luteus |  |
| Nonidet P-40 | activates | Micrococcus luteus | |
| phosphatidylethanolamine | activates | Micrococcus luteus | |
| phosphatidylglycerol | requirement | Micrococcus luteus | |
| sodium lauryl sulfate | activates | Micrococcus luteus | |
| Triton X-100 | activates | Micrococcus luteus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| GDP | - |
Micrococcus luteus | |
| phosphatidylglycerol | inhibits in excess amount | Micrococcus luteus | |
| undecaprenyl phosphate | inhibits in excess amount | Micrococcus luteus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activation, can replace Mg2+ to some extent | Micrococcus luteus | |
| Mg2+ | requirement | Micrococcus luteus | |
| Mg2+ | optimal concentration: 67 mM | Micrococcus luteus | |
| Mn2+ | activation, can replace Mg2+ to some extent | Micrococcus luteus | |
| additional information | not activated by Co2+ | Micrococcus luteus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Micrococcus luteus | involved in biosynthesis of mannan | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Micrococcus luteus | - |
Micrococcus lysodeikticus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GDPmannose + ficaprenyl phosphate | effective substrate | Micrococcus luteus | GDP + mannosyl-1-phosphorylficaprenol | - |
? | |
| GDPmannose + undecaprenyl phosphate | - |
Micrococcus luteus | GDP + D-mannosyl-1-phosphoundecaprenol | - |
r | |
| additional information | involved in biosynthesis of mannan | Micrococcus luteus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Micrococcus luteus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.9 | 7.5 | 0.06 M Tris-maleate buffer | Micrococcus luteus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.2 | 8.6 | about half-maximal activity at pH 6.2 and 8.6 | Micrococcus luteus |
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