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Literature summary for 2.4.1.50 extracted from

  • Gilkes, D.M.; Bajpai, S.; Wong, C.C.; Chaturvedi, P.; Hubbi, M.E.; Wirtz, D.; Semenza, G.L.
    Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis (2013), Mol. Cancer Res., 11, 456-466.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.50

Application

Application Comment Organism
medicine high enzyme expression in breast cancer biopsies is associated with increased risk of mortality Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine Homo sapiens
-
 UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00469
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell
-
 Homo sapiens
-
MDA-MB-435 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine
-
 Homo sapiens UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
PLOD2
-
 Homo sapiens
procollagen lysyl hydroxylase 2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens PLOD2 mRNA is induced greater than 4fold by hypoxia within 12 h and remains elevated for 72 hours of continuous hypoxia up

General Information

General Information Comment Organism
malfunction enzyme knockdown in breast cancer cells inhibits local tissue invasion Homo sapiens
metabolism procollagen lysyl hydroxylase 2 is required for the biogenesis of collagen Homo sapiens
physiological function procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. The enzyme is critical for fibrillary collagen formation by breast cancer cells, increases tumor stiffness, and is required for metastasis to lymph nodes and lungs Homo sapiens