Application | Comment | Organism |
---|---|---|
medicine | study of CGT expression and polymorphism may provide a clue for the understanding of neuropathological diseases involving myelin and myelination | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
CGT cDNA is cloned, single-copy gene | Gallus gallus |
isolation of the complete copy of CGT cDNA, which is cloned into a pCR 3.1 expression vector, transfection of polyoma virus LT antigen-expressing CHO cells and expression | Homo sapiens |
nucleotide sequence of the cDNA, single-copy gene | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | with endoplasmic reticulum retention signal | Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | final step of galactosylceramide synthesis, which plays a role in myelin formation, signal transduction and oligodendrocyte development | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | with 3 N-linked glycosylation sites | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Gallus gallus | - |
glioma cell | N-370 FG cells | Homo sapiens | - |
glioma cell | human fetal glioma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | final step of galactosylceramide synthesis, which plays a role in myelin formation, signal transduction and oligodendrocyte development | Homo sapiens | ? | - |
? | |
UDPgalactose + 2-(2-hydroxyacyl)sphingosine | - |
Gallus gallus | 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP | - |
? | |
UDPgalactose + 2-(2-hydroxyacyl)sphingosine | i.e. 2-hydroxy fatty acid ceramide | Homo sapiens | 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP | i.e. 2-hydroxy fatty acid galactosylceramide | ? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Gallus gallus |
37 | - |
assay at | Homo sapiens |