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Literature summary for 2.4.1.47 extracted from

  • Kapitonov, D.; Yu, R.K.
    Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA (1997), Biochem. Biophys. Res. Commun., 232, 449-453.
    View publication on PubMed

Application

Application Comment Organism
medicine study of CGT expression and polymorphism may provide a clue for the understanding of neuropathological diseases involving myelin and myelination Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
CGT cDNA is cloned, single-copy gene Gallus gallus
isolation of the complete copy of CGT cDNA, which is cloned into a pCR 3.1 expression vector, transfection of polyoma virus LT antigen-expressing CHO cells and expression Homo sapiens
nucleotide sequence of the cDNA, single-copy gene Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum with endoplasmic reticulum retention signal Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens final step of galactosylceramide synthesis, which plays a role in myelin formation, signal transduction and oligodendrocyte development ?
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information with 3 N-linked glycosylation sites Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Gallus gallus
-
glioma cell N-370 FG cells Homo sapiens
-
glioma cell human fetal glioma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information final step of galactosylceramide synthesis, which plays a role in myelin formation, signal transduction and oligodendrocyte development Homo sapiens ?
-
?
UDPgalactose + 2-(2-hydroxyacyl)sphingosine
-
Gallus gallus 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP
-
?
UDPgalactose + 2-(2-hydroxyacyl)sphingosine i.e. 2-hydroxy fatty acid ceramide Homo sapiens 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP i.e. 2-hydroxy fatty acid galactosylceramide ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Gallus gallus
37
-
assay at Homo sapiens