Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.41 extracted from

  • Wang, R.; Yu, C.; Zhao, D.; Wu, M.; Yang, Z.
    The mucin-type glycosylating enzyme polypeptide N-acetylgalactosaminyltransferase 14 promotes the migration of ovarian cancer by modifying mucin 13 (2013), Oncol. Rep., 30, 667-676.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + polypeptide MUC13 Homo sapiens isoform GALNT14 contributes to the glycosylation of peptide MUC13, which is significantly higher in ovarian cancer cells compared with the normal/benign ovary tissues UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide MUC13
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HO-8910 cell
-
Homo sapiens
-
HO-8910PM
-
Homo sapiens
-
OVCAR-3 cell
-
Homo sapiens
-
SKOV-3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + polypeptide MUC13 isoform GALNT14 contributes to the glycosylation of peptide MUC13, which is significantly higher in ovarian cancer cells compared with the normal/benign ovary tissues Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide MUC13
-
?

Synonyms

Synonyms Comment Organism
GALNT14
-
Homo sapiens
polypeptide N-acetylgalactosaminyltransferase 14
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens interleukin-8 has no remarkable effect on the expression of isoform GALNT14 additional information
Homo sapiens extracellular signal-regulated kinase 1/2 inhibitor modulates the expression levels of isoform GALNT14 up

General Information

General Information Comment Organism
physiological function isoform GALNT14 contributes to ovarian carcinogenesis through aberrant glycosylation of MUC13, but not through the interleukin-8 pathway Homo sapiens