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Literature summary for 2.4.1.41 extracted from

  • Tenno, M.; Ohtsubo, K.; Hagen, F.K.; Ditto, D.; Zarbock, A.; Schaerli, P.; von Andrian, U.H.; Ley, K.; Le, D.; Tabak, L.A.; Marth, J.D.
    Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity (2007), Mol. Cell. Biol., 27, 8783-8796.
    View publication on PubMed
Search for more literature for 2.4.1.41

Cloned(Commentary)

Cloned (Comment) Organism
pIMKF3 for expression in COS7 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
delta/delta mice homozygous for ppGalNAcT-1delta allele Mus musculus
ppGalNAcT-1delta allele in transgenic mice that lacks exon 3 and enzymatic activity, crossed into C57BL/6NHsd background Mus musculus
wt/delta mice heterozygous for ppGalNAcT-1delta allele Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + polypeptide Mus musculus mucin-type O-linked glycosylation of serine or threonine residues UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 isoform ppGalNAcT-1
-

Source Tissue

Source Tissue Comment Organism Textmining
brain redundancy of enzyme activity Mus musculus
-
germinal center ppGalNacT-1 activity is essential for O-glycosylation in germinal center (GC) B cells within the white pulp of the spleen and lymph nodes upon immunization, increased apoptosis of IgG bearing GC B cells and reduced IgG abundance in the absence of ppGalNAcT-1 Mus musculus
-
kidney cloned from mouse kidney total RNA Mus musculus
-
leukocyte ppGalNAcT-1 mediated O-glycosylation contributes to innate immune inflammatory response among activated endothelial cells by expression of cell surface selectin ligands on neutrophils Mus musculus
-
lymph node mostly inguinal lymph nodes, not Peyerย’s patch tissue, ppGalNAcT-1 activity regulates L-selectin ligand level in high endothelial venules that is responsible for lymph node cellularity and B- and T-cell homing Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-GalNAc + EA2
-
 Mus musculus GalNAc-EA2 + UDP
-
 ?
UDP-GalNAc + PRFODSSSKAPPPLPSPSRLPG
-
 Mus musculus GalNAc-PRFODSSSKAPPPLPSPSRLPG + UDP
-
 ?
UDP-GalNAc + selectin
-
 Mus musculus GalNAc-selectin + UDP reduced expression of cell surface E- and P-selectins (fourfold and fivefold) and L-selectins on immune cells of ppGalNAcT-1 deficient mice ?
UDP-N-acetyl-D-galactosamine + polypeptide mucin-type O-linked glycosylation of serine or threonine residues Mus musculus UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Synonyms

Synonyms Comment Organism
polypeptide GalNAc transferase
-
 Mus musculus
polypeptide GalNAcT
-
 Mus musculus
polypeptide N-acetylgalactosaminyltransferase
-
 Mus musculus
ppGalNAcT
-
 Mus musculus