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Literature summary for 2.4.1.41 extracted from

  • Briand, J.P.; Andrews, S.P.; Cahill, E.; Conway, N.A.; Young, J.D.
    Investigation of the requirements for O-glycosylation by bovine submaxillary gland UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosamine transferase using synthetic peptide substrates (1981), J. Biol. Chem., 256, 12205-12207.
    View publication on PubMed
Search for more literature for 2.4.1.41

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.06
-
 UDP-GalNAc
-
 Bos taurus
0.4
-
 myelin basic protein
-
 Bos taurus
0.4
-
 Arg-Thr-Pro-Pro-Pro
-
 Bos taurus
0.52
-
 Pro-Thr-Ala-Pro-Pro-Pro
-
 Bos taurus
1.33
-
 Ac-Thr-Pro-Pro-Pro
-
 Bos taurus
2
-
 Ac-Asn-Leu-Thr-Pro-Pro-Pro
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Bos taurus 16020
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
submaxillary gland
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + Ac-Asn-Leu-Thr-Pro-Pro-Pro
-
 Bos taurus ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + Ac-Thr-Pro-Pro-Pro
-
 Bos taurus ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + Arg-Thr-Pro-Pro-Pro
-
 Bos taurus ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + Pro-Thr-Ala-Pro-Pro-Pro
-
 Bos taurus ?
-
 ?
UDP-N-acetyl-D-galactosamine + polypeptide octapeptide Val-Thr-Pro-Arg-Thr-Pro-Pro-Pro is the best substrate, threonine cannot be glycosylated without a carboxyl triprolyl sequence, the alpha-amino acid group of the threonine must be blocked, the nature of the group NH2-terminal to the threonine affects the kinetics of the reaction, one residue can be between the threonine and the triprolyl sequence Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
UDP-N-acetyl-D-galactosamine + polypeptide O-glycosylating enzyme, acceptors: synthetic peptides in which the Thr-Pro-Pro-Pro sequence is varied Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 peptides Ac-Thr-Pro-Pro-Pro and Pro-Arg-Thr-Pro-Pro-Pro Bos taurus