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Literature summary for 2.4.1.38 extracted from

  • Li, Y.; Xue, M.; Sheng, X.; Yu, H.; Zeng, J.; Thon, V.; Chen, Y.; Muthana, M.; Wang, P.; Chen, X.
    Donor substrate promiscuity of bacterial beta1-3-N-acetylglucosaminyltransferases and acceptor substrate flexibility of beta1-4-galactosyltransferases (2016), Bioorg. Med. Chem., 24, 1696-1705 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.38

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Bos taurus
expressed in Escherichia coli BL21(DE3) cells Neisseria meningitidis
expressed in Escherichia coli BL21(DE3) cells Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide Bos taurus
-
 UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide Neisseria meningitidis
-
 UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide Helicobacter pylori
-
 UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Helicobacter pylori
-
-
-
Neisseria meningitidis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Bos taurus
Ni-NTA column chromatography Neisseria meningitidis
Ni-NTA column chromatography Helicobacter pylori

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with Glcbeta(1->3)Lacbeta-MU, GlcNAc6Sbeta(1->3)Lacbeta-MU, GlcNAc6N3beta(1->3)Lacbeta-MU, GlcNAc6NH2beta(1->3)Lacbeta-MU, GlcNAcPhPhbeta(1->3)Lacbeta-MU, GlcNGcbeta(1->3)Lacbeta-MU, GlcNH2beta(1->3)Lacbeta-MU, GalNAcbeta(1->3)Lacbeta-MU or Galbeta(1->)3Lacbeta-MU as acceptor Bos taurus ?
-
-
additional information no activity with Glcbeta(1->3)Lacbeta-MU, GlcNAcPhPhbeta(1->3)Lacbeta-MU, GlcNH2beta(1->3)Lacbeta-MU, GalNAcbeta(1->3)Lacbeta-MU or Galbeta(1->)3Lacbeta-MU as acceptor Helicobacter pylori ?
-
-
additional information no activity with GlcNAc6Sbeta(1->3)Lacbeta-MU, GlcNAc6NH2beta(1->3)Lacbeta-MU, GlcNH2beta(1->3)Lacbeta-MU, GalNAcbeta(1->3)Lacbeta-MU or Galbeta(1->)3Lacbeta-MU as acceptor Neisseria meningitidis ?
-
-
UDP-alpha-D-galactose +
-
 Helicobacter pylori ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-Glc(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 95-100% activity Neisseria meningitidis ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Neisseria meningitidis ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Helicobacter pylori ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 90-95% activity Bos taurus ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc-N3(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Neisseria meningitidis ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc-N3(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Helicobacter pylori ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc-N3(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 35-40% activity Bos taurus ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc6N3(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Helicobacter pylori ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc6N3(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 5-10% activity Neisseria meningitidis ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc6NH2(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 20% activity Helicobacter pylori ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc6OSO3-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Helicobacter pylori ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAcPh(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Neisseria meningitidis ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAcPh(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 20-25% activity Bos taurus ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAcPh(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 50% activity Helicobacter pylori ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAcPhPh(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Neisseria meningitidis ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNGc(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 75-80% activity Helicobacter pylori ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNGc(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 90-95% activity Neisseria meningitidis ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNTFA(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Helicobacter pylori ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNTFA(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 95-100% activity Neisseria meningitidis ?
-
 ?
UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNTFA-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 60-65% activity Bos taurus ?
-
 ?
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
-
 Bos taurus UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
-
 Neisseria meningitidis UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
-
 Helicobacter pylori UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?

Synonyms

Synonyms Comment Organism
beta1-4-galactosyltransferase
-
 Bos taurus
beta1-4-galactosyltransferase
-
 Neisseria meningitidis
beta1-4-galactosyltransferase
-
 Helicobacter pylori
beta4GalT
-
 Bos taurus
beta4GalT
-
 Neisseria meningitidis
beta4GalT
-
 Helicobacter pylori
LgtB
-
 Neisseria meningitidis