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Literature summary for 2.4.1.38 extracted from

  • Jiang, J.; Chen, X.; Shen, J.; Wei, Y.; Wu, T.; Yang, Y.; Wang, H.; Zong, H.; Yang, J.; Zhang, S.; Xie, J.; Kong, X.; Liu, W.; Gu, J.
    beta1,4-Galactosyltransferase V functions as a positive growth regulator in glioma (2006), J. Biol. Chem., 281, 9482-9489.
    View publication on PubMed
Search for more literature for 2.4.1.38

Activating Compound

Activating Compound Comment Organism Structure
additional information the activity of GalT V promoter can be induced by epidermal growth factor, dominant active Ras, ERK1, JNK1, and constitutively active AKT Homo sapiens

Application

Application Comment Organism
medicine GalT V might represent a target in glioma therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, expresion analysis, stable overexpression of HA-tagged GalT V in astrocytes C8-D30 and glioma cell lines U87 and U251, expression of mutant enzymes Homo sapiens

Protein Variants

Protein Variants Comment Organism
Y268G site-directed mutagenesis, the mutant enzyme is less active compared to the wild-type enzyme Homo sapiens
Y268G/Y294G site-directed mutagenesis, the mutant enzyme is less active compared to the wild-type enzyme Homo sapiens
Y294G site-directed mutagenesis, the mutant enzyme is less active compared to the wild-type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens decreasing the expression of GalT V in glioma cells promotes apoptosis, inhibits the invasion and migration and the ability of tumor formation in vivo, and reduces the activation of AKT, the enzyme functions as a glioma growth activator, overview, contribution of GalT V in the activation of AKT and MAPK kinase, contribution of serum or EGF in the transcription regulation of the GalT V gene, overview ?
-
 ?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide Homo sapiens the enzyme effectively galactosylates the GlcNAcbeta1,6Man arm of the highly branched N-glycans that are characteristic of glioma, overview UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
SHG-44 cell glioma cell line Homo sapiens
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U-251 cell glioma cell line Homo sapiens
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U-87MG cell glioma cell line Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information decreasing the expression of GalT V in glioma cells promotes apoptosis, inhibits the invasion and migration and the ability of tumor formation in vivo, and reduces the activation of AKT, the enzyme functions as a glioma growth activator, overview, contribution of GalT V in the activation of AKT and MAPK kinase, contribution of serum or EGF in the transcription regulation of the GalT V gene, overview Homo sapiens ?
-
 ?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
-
 Homo sapiens UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide the enzyme effectively galactosylates the GlcNAcbeta1,6Man arm of the highly branched N-glycans that are characteristic of glioma, overview Homo sapiens UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?

Synonyms

Synonyms Comment Organism
beta1,4-galactosyltransferase V
-
 Homo sapiens
GalT V
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 Homo sapiens