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Literature summary for 2.4.1.376 extracted from

  • Takeuchi, H.; Schneider, M.; Williamson, D.; Ito, A.; Takeuchi, M.; Handford, P.; Haltiwanger, R.
    Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling (2018), Proc. Natl. Acad. Sci. USA, 115, E8395-E8402 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.376

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cell Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-glucose + [Notch1 protein with EGF-like domain 11]-L-serine435 Homo sapiens
-
 UDP + [Notch1 protein with EGF-like domain 11]-3-O-(beta-D-glucosyl)-L-serine435
-
 ?
UDP-alpha-D-glucose + [Notch3 protein with EGF-like domain 10]-L-serine435 Homo sapiens
-
 UDP + [Notch3 protein with EGF-like domain 10]-3-O-(beta-D-glucosyl)-L-serine435
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-glucose + [Notch1 protein with EGF-like domain 11]-L-serine435
-
 Homo sapiens UDP + [Notch1 protein with EGF-like domain 11]-3-O-(beta-D-glucosyl)-L-serine435
-
 ?
UDP-alpha-D-glucose + [Notch3 protein with EGF-like domain 10]-L-serine435
-
 Homo sapiens UDP + [Notch3 protein with EGF-like domain 10]-3-O-(beta-D-glucosyl)-L-serine435
-
 ?

Synonyms

Synonyms Comment Organism
POGLUT2 formerly named KDELC1 Homo sapiens
POGLUT3 formerly named KDELC2 Homo sapiens
protein O-glucosyltransferase
-
 Homo sapiens