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Literature summary for 2.4.1.37 extracted from

  • Lowary, T.L.; Hindsgaul, O.
    Recognition of synthetic O-methyl, epimeric, and amino analogues of the acceptor alpha-L-Fuc p-(1-2)-beta-D-Gal p-OR by the blood-group A and B gene-specified glycosyltransferases (1994), Carbohydr. Res., 251, 33-67.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
octyl 3'-amino-3'-deoxy-alpha-L-fucopyranosyl-(1-2)-beta-D-galactopyranoside 93% inhibition at 0.025 mM Homo sapiens
octyl alpha-L-fucopyranosyl-(1-2)-beta-D-gulopyranoside 88% inhibition at 0.025 mM, competitive Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.022
-
 L-fucosyl-alpha-1,2-beta-D-galactosyl-O(CH2)7CH3
-
 Homo sapiens
0.538
-
 octyl 6'-O-methyl-alpha-L-fucopyranosyl-(1-2)-beta-D-galactopyranoside
-
 Homo sapiens
0.565
-
 octyl 6'-amino-6'-deoxy-alpha-L-fucopyranosyl-(1-2)-beta-D-galactopyranoside
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactose + octyl 6'-amino-6'-deoxy-alpha-L-fucopyranosyl-(1-2)-beta-D-galactopyranoside
-
 Homo sapiens UDP + alpha-D-galactosyl-1,3-[6'-amino-6'-deoxy-alpha-L-fucosyl-1,2]-beta-D-galactosyl-O(CH2)7CH3
-
 ?
UDP-galactose + octyl 6'-O-methyl-alpha-L-fucopyranosyl-(1-2)-beta-D-galactopyranoside
-
 Homo sapiens UDP + alpha-D-galactosyl-1,3-[6'-O-methyl-alpha-L-fucosyl-1,2]-beta-D-galactosyl-O(CH2)7CH3
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.005
-
 octyl 3'-amino-3'deoxy-alpha-L-fucopyranosyl-(1-2)-beta-D-galactopyranoside
-
 Homo sapiens