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Literature summary for 2.4.1.367 extracted from
- Characterization of Panax ginseng UDP-glycosyltransferases catalyzing protopanaxatriol and biosyntheses of bioactive ginsenosides F1 and Rh1 in metabolically engineered yeasts (2015), Mol. Plant, 8, 1412-1424 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A142T | the mutant of isoform UGTPg100 is inactive towards (20S)-protopanaxatriol | Panax ginseng |
| G338R | the mutant of isoform UGTPg100 is inactive towards (20S)-protopanaxatriol | Panax ginseng |
| L186S | the mutant of isoform UGTPg100 is inactive towards (20S)-protopanaxatriol | Panax ginseng |
| W205R | the mutant of isoform UGTPg100 remains active with (20S)-protopanaxatriol | Panax ginseng |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.153 | - |
(20S)-protopanaxatriol | at pH 8.0 and 35°C | Panax ginseng |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-alpha-D-glucose + (20S)-protopanaxatriol | Panax ginseng | - |
UDP + ginsenoside Rh1 | - |
? | |
| UDP-alpha-D-glucose + ginsenoside F1 | Panax ginseng | - |
UDP + (20S)-ginsenoside Rg1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Panax ginseng | A0A0K0PVW1 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-alpha-D-glucose + (20S)-protopanaxatriol | - |
Panax ginseng | UDP + ginsenoside Rh1 | - |
? | |
| UDP-alpha-D-glucose + ginsenoside F1 | - |
Panax ginseng | UDP + (20S)-ginsenoside Rg1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UGTPg100 | - |
Panax ginseng |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 9.1 | - |
(20S)-protopanaxatriol | at pH 8.0 and 35°C | Panax ginseng | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 60 | - |
(20S)-protopanaxatriol | at pH 8.0 and 35°C | Panax ginseng | |
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Release 2023.1 (January 2023)
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