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Literature summary for 2.4.1.34 extracted from

  • Garcia-Effron, G.; Lee, S.; Park, S.; Cleary, J.D.; Perlin, D.S.
    Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint (2009), Antimicrob. Agents Chemother., 53, 3690-3699.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.34

Cloned(Commentary)

Cloned (Comment) Organism
genotyping [Candida] glabrata

Protein Variants

Protein Variants Comment Organism
A1895G mutation of Fks1p [Candida] glabrata
D632E mutation of Fks1p [Candida] glabrata
D632G mutation of Fks1p [Candida] glabrata
D632Y/R1377STOP mutation of Fks2p and Fks1p [Candida] glabrata
D666E mutation of Fks2p [Candida] glabrata
D666G mutation of Fks2p [Candida] glabrata
F625S mutation of Fks1p [Candida] glabrata
F659del mutation of Fks2p [Candida] glabrata
F659S mutation of Fks2p [Candida] glabrata
F659V mutation of Fks2p [Candida] glabrata
G1894T mutation of Fks1p [Candida] glabrata
additional information inhibition profile of wild-type and mutant enzymes with antifungal drugs, overview [Candida] glabrata
P667T mutation of Fks2p [Candida] glabrata
S629P mutation of Fks1p [Candida] glabrata
S663P mutation of Fks2p [Candida] glabrata
T1874C mutation of Fks1p [Candida] glabrata
T1885C mutation of Fks1p [Candida] glabrata
T1896G mutation of Fks1p [Candida] glabrata
W1375L mutation of Fks2p [Candida] glabrata

Inhibitors

Inhibitors Comment Organism Structure
anidulafungin an antifungal echinocandin drug, inhibition profile of wild-type and mutant enzymes [Candida] glabrata
caspofungin an antifungal echinocandin drug, inhibition profile of wild-type and mutant enzymes [Candida] glabrata
micafungin an antifungal echinocandin drug, inhibition profile of wild-type and mutant enzymes [Candida] glabrata

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics of wild-type and mutant enzymes, overview [Candida] glabrata
0.1
-
 [(1,3)-beta-D-glucosyl]n enzyme from wild-type strain 3168 [Candida] glabrata
0.12
-
 [(1,3)-beta-D-glucosyl]n enzyme from wild-type strain 218 [Candida] glabrata
0.13
-
 [(1,3)-beta-D-glucosyl]n enzyme from wild-type strain 90030 [Candida] glabrata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + [(1,3)-beta-D-glucosyl]n [Candida] glabrata
-
 UDP + [(1,3)-beta-D-glucosyl]n+1
-
 ?

Organism

Organism UniProt Comment Textmining
[Candida] glabrata
-
 Fifteen clinical strains, e.g. wild-type strains 90030, 218, and 3168
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + [(1,3)-beta-D-glucosyl]n
-
 [Candida] glabrata UDP + [(1,3)-beta-D-glucosyl]n+1
-
 ?

Synonyms

Synonyms Comment Organism
1,3-beta-D-glucan synthase
-
 [Candida] glabrata

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 inhibitory potency of antifungal echinocandin drugs on different wild-type and on mutant strains, overview [Candida] glabrata additional information