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Literature summary for 2.4.1.34 extracted from
- FsFKS1, the 1,3-beta-glucan synthase from the caspofungin-resistant fungus Fusarium solani (2006), Eukaryot. Cell, 5, 1036-1042.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Caspofungin acetate | IC50: 30nM | Aspergillus fumigatus |  |
| Caspofungin acetate | - |
Candida albicans | |
| additional information | not inhibited by caspofungin acetate (CFA) | Fusarium solani |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Fusarium solani | cell wall biosynthetic enzyme | ? | - |
? | |
| additional information | Aspergillus fumigatus | cell wall biosynthetic enzyme | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus fumigatus | - |
- |
- |
| Candida albicans | - |
- |
- |
| Fusarium solani | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | cell wall biosynthetic enzyme | Fusarium solani | ? | - |
? | |
| additional information | cell wall biosynthetic enzyme | Aspergillus fumigatus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta(1,3)-D-glucan synthase | - |
Candida albicans |
| beta(1,3)-D-glucan synthase | - |
Fusarium solani |
| beta(1,3)-D-glucan synthase | - |
Aspergillus fumigatus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00003 | - |
IC50: 30nM | Aspergillus fumigatus | Caspofungin acetate | |
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