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Literature summary for 2.4.1.338 extracted from
- Cloning, expression and medium optimization of validamycin glycosyltransferase from Streptomyces hygroscopicus var. jinggangensis for the biotransformation of validoxylamine A to produce validamycin A using free resting cells (2013), Biores. Technol., 131, 13-20.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Streptomyces hygroscopicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | - |
Streptomyces hygroscopicus |  |
| Cu2+ | - |
Streptomyces hygroscopicus | |
| Li+ | - |
Streptomyces hygroscopicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | promotes enzyme activity | Streptomyces hygroscopicus | |
| Fe2+ | promotes enzyme activity | Streptomyces hygroscopicus | |
| Mg2+ | promotes enzyme activity | Streptomyces hygroscopicus | |
| Mn2+ | promotes enzyme activity | Streptomyces hygroscopicus | |
| Zn2+ | promotes enzyme activity | Streptomyces hygroscopicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 47000 | - |
x * 47000, SDS-PAGE | Streptomyces hygroscopicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-alpha-D-glucose + validoxylamine A | Streptomyces hygroscopicus | - |
UDP + validamycin A | - |
? | |
| UDP-alpha-D-glucose + validoxylamine A | Streptomyces hygroscopicus 5008 | - |
UDP + validamycin A | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces hygroscopicus | - |
variant Streptomyces hygroscopicus jinggangensis | - |
| Streptomyces hygroscopicus 5008 | - |
variant Streptomyces hygroscopicus jinggangensis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-alpha-D-glucose + validoxylamine A | - |
Streptomyces hygroscopicus | UDP + validamycin A | - |
? | |
| UDP-alpha-D-glucose + validoxylamine A | - |
Streptomyces hygroscopicus 5008 | UDP + validamycin A | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 47000, SDS-PAGE | Streptomyces hygroscopicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| valG | - |
Streptomyces hygroscopicus |
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Release 2023.1 (January 2023)
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