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Literature summary for 2.4.1.318 extracted from

  • Bate, N.; Butler, A.R.; Smith, I.P.; Cundliffe, E.
    The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin (2000), Microbiology, 146, 139-146.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30120
-
x * 30120, calculated from sequence Streptomyces fradiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dTDP-beta-L-mycarose + demethyllactenocin Streptomyces fradiae the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin dTDP + demethylmacrocin
-
?
dTDP-beta-L-mycarose + demethyllactenocin Streptomyces fradiae T59235 the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin dTDP + demethylmacrocin
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces fradiae Q9XC67 wild-type strain also known as C373.1
-
Streptomyces fradiae T59235 Q9XC67 wild-type strain also known as C373.1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTDP-beta-L-mycarose + demethyllactenocin the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin Streptomyces fradiae dTDP + demethylmacrocin
-
?
dTDP-beta-L-mycarose + demethyllactenocin dTDP-beta-L-mycarose i.e. dTDP-2,6-dideoxy-3-C-methyl-beta-L-ribo-hexose. demethyllactenocin i.e. [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside Streptomyces fradiae dTDP + demethylmacrocin
-
?
dTDP-beta-L-mycarose + demethyllactenocin the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin Streptomyces fradiae T59235 dTDP + demethylmacrocin
-
?
dTDP-beta-L-mycarose + demethyllactenocin dTDP-beta-L-mycarose i.e. dTDP-2,6-dideoxy-3-C-methyl-beta-L-ribo-hexose. demethyllactenocin i.e. [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside Streptomyces fradiae T59235 dTDP + demethylmacrocin
-
?

Subunits

Subunits Comment Organism
? x * 30120, calculated from sequence Streptomyces fradiae

Synonyms

Synonyms Comment Organism
tylC5
-
Streptomyces fradiae
tylCV
-
Streptomyces fradiae

General Information

General Information Comment Organism
physiological function the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin Streptomyces fradiae