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Literature summary for 2.4.1.290 extracted from

  • Weerapana, E.; Glover, K.J.; Chen, M.M.; Imperiali, B.
    Investigating bacterial N-linked glycosylation: synthesis and glycosyl acceptor activity of the undecaprenyl pyrophosphate-linked bacillosamine (2005), J. Am. Chem. Soc., 127, 13766-13767.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol Campylobacter jejuni
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 UDP + N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
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 ?

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni
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 gene pglA located in the pgl gene cluster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
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 Campylobacter jejuni UDP + N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
-
 ?

General Information

General Information Comment Organism
metabolism the enzyme is part of the enzyme system catalyzing the synthesis of the Und-PP-linked heptasaccharide GalNAc-alpha1,4- GalNAc-alpha1,4-(Glcbeta1,3)-GalNAc-alpha1,4-Gal-NAc-alpha1,4-GalNAc-R1,3-Bac-R1,PP-Und, where Bac is the unusual sugar bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) that is only found in specific bacterial systems Campylobacter jejuni