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Literature summary for 2.4.1.290 extracted from

  • Morrison, J.P.; Troutman, J.M.; Imperiali, B.
    Development of a multicomponent kinetic assay of the early enzymes in the Campylobacter jejuni N-linked glycosylation pathway (2010), Bioorg. Med. Chem., 18, 8167-8171.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.290

Inhibitors

Inhibitors Comment Organism Structure
additional information screening for inhibitors of the first four steps in the N-linked glycosylation system pathway, overview Campylobacter jejuni

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol Campylobacter jejuni
-
 UDP + N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
-
 ?

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni
-
 gene pglA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information development and optimization of an assay method to monitor the transfer of GalNAc from the hydrophilic UDP-linked carrier to the lipophilic UndPP-diNAcBac, i.e. 2,4-diacetamido-2,4,6-trideoxyglucose Campylobacter jejuni ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
-
 Campylobacter jejuni UDP + N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
-
 ?

Synonyms

Synonyms Comment Organism
PglA
-
 Campylobacter jejuni

General Information

General Information Comment Organism
metabolism PglF, PglE, PglD, PglC and PglA are the enzymes involved in the biosynthesis of an undecaprenyl diphosphate-linked disaccharide Campylobacter jejuni
physiological function the enzyme is involved in a general N-linked glycosylation system that plays a role in pathogenicity Campylobacter jejuni