Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.255 extracted from

  • Constable, S.; Lim, J.M.; Vaidyanathan, K.; Wells, L.
    O-GlcNAc transferase regulates transcriptional activity of human Oct4 (2017), Glycobiology, 27, 927-937 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.255

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + [octamer-binding protein 4]-L-serine Homo sapiens octamer-binding protein 4 (Oct4) is one of the key transcription factors required for pluripotency of embryonic stem cell and more recently, the generation of induced pluripotent stem cells. The action of Oct4 is modulated by the addition of several post-translational modifications, including O-GlcNAc. Human Oct4 activity is regulated by O-linked N-acetylglucosamine transferase by a mechanism that is distinct from mouse Oct4 UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + [octamer-binding protein 4]-L-threonine Homo sapiens octamer-binding protein 4 (Oct4) is one of the key transcription factors required for pluripotency of embryonic stem cell and more recently, the generation of induced pluripotent stem cells. The action of Oct4 is modulated by the addition of several post-translational modifications, including O-GlcNAc. The action of Oct4 is modulated by the addition of several post-translational modifications, including O-GlcNAc. Human Oct4 activity is regulated by O-linked N-acetylglucosamine transferase by a mechanism that is distinct from mouse Oct4 UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15294
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + [octamer-binding protein 4]-L-serine
-
 Homo sapiens UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + [octamer-binding protein 4]-L-serine octamer-binding protein 4 (Oct4) is one of the key transcription factors required for pluripotency of embryonic stem cell and more recently, the generation of induced pluripotent stem cells. The action of Oct4 is modulated by the addition of several post-translational modifications, including O-GlcNAc. Human Oct4 activity is regulated by O-linked N-acetylglucosamine transferase by a mechanism that is distinct from mouse Oct4 Homo sapiens UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + [octamer-binding protein 4]-L-threonine
-
 Homo sapiens UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + [octamer-binding protein 4]-L-threonine octamer-binding protein 4 (Oct4) is one of the key transcription factors required for pluripotency of embryonic stem cell and more recently, the generation of induced pluripotent stem cells. The action of Oct4 is modulated by the addition of several post-translational modifications, including O-GlcNAc. The action of Oct4 is modulated by the addition of several post-translational modifications, including O-GlcNAc. Human Oct4 activity is regulated by O-linked N-acetylglucosamine transferase by a mechanism that is distinct from mouse Oct4 Homo sapiens UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine
-
 ?

Synonyms

Synonyms Comment Organism
O-GlcNAc transferase
-
 Homo sapiens