Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine | Homo sapiens | essential enzyme that catalyzes the covalent bonding of N-acetylglucosamine to the hydroxyl group of a serine or threonine in the target protein. It plays an important role in many important cellular physiological catalytic reactions | UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine | - |
? | |
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine | Homo sapiens | essential enzyme that catalyzes the covalent bonding of N-acetylglucosamine to the hydroxyl group of a serine or threonine in the target protein. It plays an important role in many important cellular physiological catalytic reactions | UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15294 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine | essential enzyme that catalyzes the covalent bonding of N-acetylglucosamine to the hydroxyl group of a serine or threonine in the target protein. It plays an important role in many important cellular physiological catalytic reactions | Homo sapiens | UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine | - |
? | |
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine | Lys634, Asn838, Gln839, Lys842, His901, and Asp925 play an important role in stabilizing UDP at the active site of the enzyme via hydrogen bonds and pi-pi interactions. The binding free energy of the UDP-enzyme complex is mainly constituted by electrostatic interactions and side chain effects. The uridine diphosphate release mechanism is studied | Homo sapiens | UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine | - |
? | |
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine | essential enzyme that catalyzes the covalent bonding of N-acetylglucosamine to the hydroxyl group of a serine or threonine in the target protein. It plays an important role in many important cellular physiological catalytic reactions | Homo sapiens | UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine | - |
? | |
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine | Lys634, Asn838, Gln839, Lys842, His901, and Asp925 play an important role in stabilizing UDP at the active site of the enzyme via hydrogen bonds and pi-pi interactions. The binding free energy of the UDP-enzyme complex is mainly constituted by electrostatic interactions and side chain effects. The uridine diphosphate release mechanism is studied | Homo sapiens | UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine | - |
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Synonyms | Comment | Organism |
---|---|---|
O-GlcNAc transferase | - |
Homo sapiens |
O-linked N-acetylglucosamine transferase | - |
Homo sapiens |
O-N-acetylglucosamine (O-GlcNAc) transferase | - |
Homo sapiens |
OGT | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | O-N-acetylglucosamine (O-GlcNAc) transferase is the only one enzyme responsible for O-GlcNAc glycosylation in more than 1000 proteins and plays an extremely significant role in biochemical processes | Homo sapiens |