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Literature summary for 2.4.1.255 extracted from

  • Dorfmueller, H.C.; Borodkin, V.S.; Blair, D.E.; Pathak, S.; Navratilova, I.; van Aalten, D.M.
    Substrate and product analogues as human O-GlcNAc transferase inhibitors (2010), Amino Acids, 40, 781-792.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.255

Cloned(Commentary)

Cloned (Comment) Organism
-
 Xanthomonas campestris pv. campestris

Crystallization (Commentary)

Crystallization (Comment) Organism
vapour diffusion crystallisation experiments are performed Xanthomonas campestris pv. campestris

Protein Variants

Protein Variants Comment Organism
D471A D471A-XcOGT Xanthomonas campestris pv. campestris

Inhibitors

Inhibitors Comment Organism Structure
additional information testing UDP-GlcNAc/UDP analogues and evaluate their inhibitory properties and structural binding modes in vitro. These analogues are not active on living cells, they inhibit the enzyme in the micromolar range and together with the structural data provide useful templates for further optimisation Xanthomonas campestris pv. campestris
UDP product inhibition Xanthomonas campestris pv. campestris
UDP-1-deoxy-1-methylene-N-acetyl-alpha-D-glucosamine binds weakly Xanthomonas campestris pv. campestris
UDP-1-deoxy-1-thio-N-acetyl-alpha-D-glucosamine binds weakly Xanthomonas campestris pv. campestris

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic experiments using recombinant hOGT/XcOGT Xanthomonas campestris pv. campestris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Xanthomonas campestris pv. campestris enzyme transfers GlcNAc onto substrate proteins using UDP-GlcNAc as the sugar donor ?
-
 ?

Organism

Organism UniProt Comment Textmining
Xanthomonas campestris pv. campestris
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Xanthomonas campestris pv. campestris

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme transfers GlcNAc onto substrate proteins using UDP-GlcNAc as the sugar donor Xanthomonas campestris pv. campestris ?
-
 ?
additional information UDP-1-deoxy-1-thio-N-acetyl-alpha-D-glucosamine is no substrate Xanthomonas campestris pv. campestris ?
-
 ?

Synonyms

Synonyms Comment Organism
O-GlcNAc transferase
-
 Xanthomonas campestris pv. campestris
OGT
-
 Xanthomonas campestris pv. campestris
XcOGT hOGT homologue Xanthomonas campestris pv. campestris
XcOGT protein
-
 Xanthomonas campestris pv. campestris