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Literature summary for 2.4.1.250 extracted from

  • Newton, G.L.; Koledin, T.; Gorovitz, B.; Rawat, M.; Fahey, R.C.; Av-Gay, Y.
    The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA) (2003), J. Bacteriol., 185, 3476-3479.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate Mycolicibacterium smegmatis 1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, mycothiol biosynthesis 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
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Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate 1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, mycothiol biosynthesis Mycolicibacterium smegmatis 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
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General Information

General Information Comment Organism
malfunction characterization of mutant mshA::Tn5 which is defective in MshA produces no measurable amount of the pseudodisaccharide precursors of mycothiol, 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside and 1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside Mycolicibacterium smegmatis